2,3-dinor Thromboxane B2 EIA Kit
Stability : 1 year
TXA2 is rapidly hydrolyzed non-enzymatically to form TXB2. Although it is common to estimate TXA2 levels by measuring TXB2, most of the TXB2 measured is due to ex vivo platelet activation or intra-renal production. Measurement errors are compounded by the fact that normal concentrations of circulating TXB2 are extremely low (1-2 pg/ml), and highly transient (t½ = 5-7 minutes). To circumvent this problem, it is necessary to measure a metabolite that cannot be formed by platelets or by the kidney. TXB2 may be metabolized by 11-hydroxy thromboxane dehydrogenase to form 11-dehydro TXB2, or by β-oxidation to form 2,3-dinor TXB2. Infusion studies using TXB2 have shown that both metabolites are formed equally, but that the circulating half-life of 2,3-dinor TXB2 is shorter (t½ = 15 minutes). Therefore, measurement of 2,3-dinor TXB2 will give a more episodic indication of TXA2 production. Because plasma concentrations of 2,3-dinor TXB2 are low (and artifactual TXB2 concentrations may be high), it may be necessary to purify and concentrate plasma samples. It is also recommended to purify urine samples to remove possible crossreacting metabolites and TXB2 from the sample.
Storage : -20°C
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