Rattan tea extract pharmacological efficac

Pharmacological experiments show that high purity dihydromyricetin on Bacillus subtilis, Staphylococcus aureus, Salmonella, Escherichia coli, Agrobacteria, Saccharomyces cerevisiae, Rhodotorula, Penicillium, Aspergillus niger, Aspergillus flavors, Mucor, and Rhizopus have a bacteriostatic effect, especially for Gram-positive, Gram-negative cocci or Bacillus effect is obvious.  

 Antipyretic  Analgesic and anti-inflammatory effects studies have shown that dihydromyricetin on mouse oat oil otic ear edema, rat carrageenan, formaldehyde foot ring swelling and peritoneal capillary permeability acute, Subacute inflammatory exudation process are inhibited; on the mouse acidic writhing reaction and hot water reaction showed a certain analgesic effect, can improve the mouse pain valve level.

In addition, the antipyretic experiment of typhoid and paratyphoid fever (A and B) triplet vaccine showed that intraperitoneal injection of ethanol extract of Tengcha (mainly dihydromyricetin) could significantly reduce the body temperature of rabbits The  rattan tea 3Expectorant cough effect  (1.0g / Kg0.5g / Kg) and the positive control drug ammonium chloride (1.0g / kg) of the phenol red excretion of the dihydromyricetin size dose group (1.0g / Kg0.5g / Kg) and the positive control drug ammonium chloride (1.0g / Kg) , Compared with the control group were significantly increased, confirmed that dihydromyricetin has a significant expectorant effect; while dihydromyricetin can significantly extend the cough latency and reduce the number of a cough, including high-dose group (1.0g / Kg) cough effect Strength and control group cough must clear quite.   

The regulation of blood glucose the regulation of blood glucose and blood lipids: mice pharmacological experiments show that dihydromyricetin can significantly inhibit the alloxan, epinephrine, streptozotocin and other mice induced by elevated blood glucose, while increasing serum Insulin levels, pancreatic tissue lymphocyte infiltration was significantly reduced, the inflammatory response was significantly reduced, the number of islets increased significantly. (TC) and high-density lipoprotein cholesterol (HDL2C) in a serum of rats with hyperglycemia induced by streptozotocin had no significant effect on serum triglyceride (TG) content.   

Liver and liver function:  Dihydromyricetin on the cultured rat hepatocytes in vitro toxicity of carbon tetrachloride, D2 galactosamine and lipopolysaccharide-induced liver injury in mice have a significant protective effect. Dihydromyricetin can protect the liver, accelerate the rapid decomposition of ethanol metabolites acetaldehyde, into non-toxic substances, reduce the damage to liver cells. In addition, dihydromyricetin can improve liver cell damage caused by increased serum lactate dehydrogenase activity, inhibition of liver M cell collagen fiber formation, which play a role in liver protection, a significant reduction in ethanol damage to the liver, So that the normal state of the liver quickly recovered. 

Antioxidant effect:  Dihydromyricetin, 95% purity, could inhibit the formation of malondialdehyde (MDA) in the myocardium, liver, and brain tissue homogenate of rats, and inhibited with the increase of dihydromyricetin concentration (DPPH) free radicals in the test system was increased by the effect of MDA on the content of MDA. Dihydromyricetin can significantly inhibit the formation of MDA in oil, with the content of dihydromyricetin (60% ~ 90%) increased antioxidant effect on animal oil and vegetable oil has a strong antioxidant effect. 

 Anti-tumor effect:  In recent years, anti-tumor pharmacodynamics study found that one of its active ingredients, snake grapevine small molecule compounds have a strong anti-cancer effect. In vitro antitumor effect study found that the compound can inhibit the growth of tumor blood vessels, regulate and enhance the role of cellular immune function to improve the effectiveness of tumor therapy and improve the patient’s life disease purposes, in leukemia and nasopharyngeal carcinoma and other tumor model test studies are Showing a significant anti-tumor effect.