Biochemistry of microbial Itaconic acid production

Itaconic acid is an unsaturated dicarbonic acerbic which has a top abeyant as a biochemical architecture block, because it can be acclimated as a monomer for the assembly of a deluge of articles including resins, plastics, paints, and constructed fibers.
The levels of Itaconic acid which were accomplished with A. terreus are currently bound to about 85 g/L. Although this is already a abundant bulk it cannot be compared with the assembly of citric acerbic area titers over 200 g/L are steadily acquired in automated processes. Transferred to the Itaconic acid assembly a acute abstract titer of about 240 g/L should be achievable. This ambition could be accomplished by added ancestry of currently absolute strains or targeted abiogenetic engineering.
Itaconic acid as a renewable amoebic acerbic is of growing absorption for the actinic industry, because of its abeyant to alter awkward oil based articles like acrylic acid. Up to now, the bacillus based processes were bigger by classical ache ancestry and optimizations of the beverage strategies and conditions. Especially the ability about the biotechnological action including oxygen supply, media compositions, and altered bioreactor systems was decidedly expanded.