Effects of magnesium-aluminum hydroxide acrid on assimilation of rufloxacin

The present abstraction was advised to actuate the furnishings of an acrid abeyance absolute magnesium hydroxide and aluminum hydroxide (30 ml of Maalox) on the articulate bioavailability of rufloxacin (400 mg). Rufloxacin was administered orally to 12 advantageous volunteers according to a randomized, balanced, crossover design.
Three treatments were administered to anniversary subject, with a 10-day accident aeon amid treatments; the treatments included rufloxacin alone, rufloxacin taken 5 min afterwards antacid, and rufloxacin taken 4 h afore antacid. Administering of acrid aural 5 min afore the administering of rufloxacin resulted in a abundant abatement in rufloxacin absorption, with a beggarly percent about bioavailability compared with ascendancy ethics of 64% (range, 42 to 77%).
Administration of acrid 4 h afterwards the administering of rufloxacin hardly afflicted the assimilation of the quinolone (mean about bioavailability, 87%; range, 51 to 110%). Antacids that accommodate magnesium and aluminum salts abate the assimilation of rufloxacin. The admeasurement of this alternation depends on the time that elapses amid administering of the two drugs.