Physical and actinic adherence of esomeprazole sodium solutions

To appraise the adherence of esomeprazole sodium in 5% dextrose, 0.9% sodium chloride, and lactated Ringer's injection, at 2 concentrations, at allowance temperature and if refrigerated.
Triplicate samples of esomeprazole 0.4 and 0.8 mg/mL as the sodium alkali were able in the solutions required. Adherence evaluations were performed initially, over 2 canicule stored at 23 degrees C, and over 5 canicule stored at 4 degrees C. Physical adherence was adjourned application turbidimetric and chapped measurement, as able-bodied as beheld observation. Actinic adherence was evaluated by stability-indicating high-performance aqueous chromatography.
The samples in all 3 beverage solutions were physically abiding throughout the study. None of the samples had affirmation of arresting brume or particulates. Most samples developed a slight chicken birthmark aural 24 hours, but this birthmark was not accompanied by an boundless accident of biologic content. The esomeprazole sodium samples in all 3 beverage solutions apparent beneath than 7% accident over 2 canicule at 23 degrees C and over 5 canicule at 4 degrees C.