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H-1152 (hydrochloride)

Molecular Formula : C16H21N3O2S • 2HCl
Formula Weight : 392.3g/mol
Specification :
Formulation:A crystalline solid
Purity:≥95%
Stability:2 years
Description : 
It is a more potent inhibitor of ROCK than either Y-27632 (Ki = 140 nM) or HA-1077 (Ki = 330 nM).2 H-1152 poorly inhibits PKA, PKC, and myosin light chain kinase (Ki = 0.63, 9.27, and 10.1 μM, respectively).2 It has been used to examine the role of ROCK in such diverse processes as stress fiber assembly,3 vasoconstriction,4 as well as spontaneously tonic smooth muscle5 and neurite extension.6
Storage : -20°C

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