SET7/9 (FL) Polyclonal Antibody
Formulation : protein-A purified IgG in 500 μl TBS, pH 7.4, containing 50 % glycerol, 0.5 mg/ml BSA, and 0.02 % sodium azide
Stability : 1 year
Storage : -20°C
WB · Diverse signal transduction pathways impinging on the N-terminal tails of histones lead to a number of post-translational modifications including acetylation, phosphorylation, poly (ADP-ribosylation), ubiquitination, and methylation. These modifications play critical roles in regulating chromatin structure and gene expression.1 Histone methyltransferases selectively methylate evolutionarily conserved arginine or lysine residues, primarily in the N-terminal tails of histones H3 and H4. SET7/9 utilizes S-adenosylmethionine to methylate histone H3 at lysine 4.2,3,4 Human SET7/9 is a 366 amino acid protein with observed migration on SDS-PAGE at 49 kDa.
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