NF-κB (p65) (Ser276) Inhibitory Peptide Set
Formulation : A lyophilized solid
Stability : 1 year
NF-κB has been shown to regulate the expression of a number of genes whose products are involved in inflammation, viral replication, carcinogenesis, antiapoptosis, invasion, and metastasis. Specific adhesion molecules, chemokines, inflammatory cytokines, and cell cycle regulatory genes are affected. Thus, agents that can suppress NF-κB activation have the potential to be treatments for inflammatory diseases and cancer. The Ser276 site of p65 is phosphorylated during NF-κB activation, allowing p65 nuclear translocation. This p65 inhibitory peptide contains a Ser276 site that is phosphorylated during NF-κB activation, thereby blocking p65 Ser276 phosphorylation.1,2 The NF-kB (p65) (Ser276) inhibitory peptide, also known as PTD-p65-P1, also contains a protein transduction (PTD) sequence (DRQIKIWFQNRRMKWKK) derived from antennapedia which renders the peptide cell permeable.3 The control peptide consists of only the PTD sequence.
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