HDAC4 (human recombinant)
Formulation:2 µg in 25 mM Tris-HCl, pH 8.0, 100 mM sodium chloride, containing 0.05% Tween-20, and 50% glycerol
Purity:>50% by SDS-PAGE
HDAC4 is a Class IIa HDAC which is homologous to yeast Hda 1 and is larger in size than the other 2 classes of HDACs. Class IIa HDACs contain a highly conserved C-terminal deacetylase catalytic domain (~420 amino acids) and an N-terminal domain with no similarity to HDACs in other classes.1,2 Class II HDACs can shuttle between the nucleus and cytoplasm, suggesting potential extranuclear functions by regulating the acetylation status of nonhistone substrates. By modifying chromatin structure and other nonhistone proteins, HDACs play important roles in controlling complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation. Considering these major roles, it is conceivable that dysregulation of HDACs and subsequent imbalance of acetylation and deacetylation may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases.
Storage : -80°C
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