LSD1 (human recombinant)

Stability : 6 months
Formulation :
50 mM sodium phosphate, pH 7.2 containing 100 mM sodium chloride and 20% glycerol
Description :
LSD1 belongs to the family of flavin adenine dinucleotide (FAD)-dependent amine oxidases that include monoamine oxidases (MAOs) and polyamine oxidase (PAO). LSD1 is a component of several histone deacetylase co-repressor complexes, including histone deacetylases 1 and 2, CtBP, and the neuronal CoREST complexes. LSD1, with the help of its cofactor CoREST, specifically demethylates mono- and dimethylated histone H3 lysine 4 (H3-K4), resulting in transcriptional repression. In addition to demethylating histones, LSD1 controls the tumor suppressor activity of p53 by demethylating a specific p53 lysine residue (LYS370).  This activity does not seem to require CoREST and p53 demethylation of LYS370 prevents p53 interaction with its co-activator 53BP1 to induce apoptosis.
Purity : ≥50%
Storage : -80°C