PtdIns-(4,5)-P2 Binding Protein
Product Description
Stability : 1 year
Formulation : A solution in PBS, pH 7.4, containing 20% glycerol
Description:
PtdIns-(4,5)-P2 Binding Protein contains a highly specific PH domain that recognizes and binds PtdIns-(4,5)-P2 (see Figure 1). PtdIns phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(4,5)-P2 can be phosphorylated by phosphoinositide (PI)-3-kinase to make PtdIns-(3,4,5)-P3 which initiates an intricate signalling cascade that has been implicated in cancer PtdIns-(4,5)-P2 binding protein can be used in in vitro assays for the detection of PtdIns-(4,5)-P2 in PI3-kinase and PTEN phosphatase assays.
Purity : >95%
Storage : -80°C
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