PtdIns-(4)-P1 Binding Protein
Product Description
Stability : 1 year
Formulation : A solution in PBS containing 1 mM EDTA, 2 mM GSH, and 25% glycerol
Description:
PtdIns-(4)-P1 Binding Protein contains a highly specific PH domain that recognizes and binds PtdIns-(4)-P1. PIPs represent a small percentage of total membrane phospholipids however, they play a critical role in the generation and transmission of cellular signals. PtdIns-(4)-P1 can phosphorylated by kinases to give bi- and triphosphates such as PtdIns-(4,5)-P2 and PtdIns-(3,4,5)-P3. Phosphorylation of PtdIns-(4)-P1 by phosphoinositide (PI)3-kinase to make PtdIns-(3,4)-P2 initiates an intricate signalling cascade that has been implicated in cancer.
Purity : >90%
Storage:-80°C
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