Soluble Epoxide Hydrolase (murine recombinant from E. coli)

Stability : 6 months
Formulation : TBS buffer at pH 7.4, containing 20% glycerol
Description :
Mammalian soluble epoxide hydrolase (sEH) is a member of the α/β-hydrolase fold family of enzymes that catalyze the hydrolysis of exogenous and endogenous epoxides to vicinal diols. sEH is a homodimer consisting of two domains. The C-terminal domain is responsible for the epoxide hydrolase activity while the N-terminal domain has a catalytic center with phosphatase activity. Endogenous substrates for sEH include epoxyeicosatrienoic acids (EETs) which are known for their vasodialatory effects as well as for their anti-inflammatory actions. Inhibition of sEH in animal models was shown to treat hypertension and vascular inflammation, as well as related syndromes, validating sEH as a highly promising target for drug development.
Purity : ≥95%
Storage : -80°C