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Cytochrome P450 2A6 (human) Yeast Reductase
Stability : 2 yearsDescription : Cytochrome P450 2A6 is principally involved in the break down of nicotine in the bloodstream as it circulates through the liver. Oxidation of nicotine by this P450 leads to detoxication, but the enzyme also activates tobacco-specific procarcinogens to mutagenic
Cytochrome P450 1B1 (human) Yeast Reductase
Stability : 2 yearsDescription : Human cytochrome P450 1B1 (CYP1B1) is found mainly in extrahepatic tissues and is overexpressed in a variety of human tumors. Metabolic activation of 17β-estradiol (E2) to 4-hydroxy E2 by CYP1B1 has been postulated to be an important factor in mammary carcinogenesis
Cytochrome P450 2C18 (human) Yeast Reductase
Stability : 2 yearsDescription : This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the
Cytochrome P450 2B6 (human) Yeast Reductase
Stability : 2 yearsDescription : Mechanism-based inhibition of CYP2B6 in human liver microsomes by thienopyridine antiplatelet agents ticlopidine and clopidogrel and the thiolactone metabolites of those two agents plus that of prasugrel were investigated by determining the time- and concentration-
Cytochrome P450 2B6 (human) Human Reductase with Cytochrome b5
Stability : 2 yearsDescription : Human P450 2B6 is a polymorphic enzyme involved in the oxidative metabolism of a number of clinically relevant substrates. The lysine 262-to-arginine mutant of cytochrome P450 2B6 (P450 2B6.4) has been shown to have differential effects on P450 2B6 catalytic
Cytochrome P450 2D6 (human) Yeast Reductase
Stability : 2 yearsDescription : Cytochrome P450 2D6 (CYP2D6), a member of the cytochrome P450 mixed-function oxidase system, is one of the most important enzymes involved in the metabolism of xenobiotics in the body. Whilst CYP2D6 is involved in the oxidation of a wide range of substrates of all
Cytochrome P450 2C9 (human) Yeast Reductase
Stability : 2 yearsDescription : CYP2C9 is an important cytochrome P450 enzyme with a major role in the oxidation of both xenobiotic and endogenous compounds. CYP2C9 makes up about 18% of the cytochrome P450 protein in liver microsomes. Some 100 therapeutic drugs are metabolized by CYP2C9,
Cytochrome P450 2C8 (human) Yeast Reductase
Stability : 2 yearsDescription : Cytochrome P450 2C8 is involved in the metabolism of drugs such as paclitaxel, repaglinide, rosiglitazone, and cerivastatin, among others. An in vitro assessment of 209 frequently prescribed drugs and related xenobiotics was carried out to examine their potential to
Cytochrome P450 3A4 (human) Human Reductase with Cytochrome b5
Stability : 2 yearsDescription : Cytochrome P450(CYP)3A4 is one of the CYP enzymes catalyzing oxidative metabolism, and involved in the metabolism of many drugs. Among benzodiazepines, alprazolam, triazolam, brotizolam and midazolam are mainly metabolished by CYP3A4, and quazepam, diazepam and
